How do you LEAVE everything and follow Jesus?

It is a principle decision to follow Jesus at all cost and to do what He guides you into doing.
Firstly you need to dedicate your life to Jesus and obey Him, live holy and righteous in obedience to His words, as written in the gospels: Matthew, Mark, Luke and John.
The Holy Spirit will also convict you in your heart of sin, righteousness and judgment. Obey His voice speaking in you.
Jesus will reveal Himself to you more and more and convict you of things that you need to stop doing, bad habits, thoughts etc. Obey do not resist. If you need to stop hobbies and get rid of wrong friends, LEAVE them behind.
LEAVE your own interests and desires behind and seek to please Jesus.
Ultimately He may guide to go to wherever He wants to use you. Then, LEAVE everything behind.
Make sure that you follow Jesus and not your own mind. You will eventually need to leave your own mind behind and focus only on the guidance of the Holy Spirit.

Jesus does not lead you to leave your responsibilities. You need to take care of your family and honor your commitments, work and earn an honorable living. He will not allow us to desert our responsibilities.

Get to know the voice of Jesus and follow him. His sheep do. John 10:27.
Those who follow Jesus do nothing on their own initiative, they do what the Holy Spirit guides them to do.

How does God speak?

God speaks to us in many ways but we do not take notice.

“Indeed God speaks once,
Or twice, yet no one notices it.
“In a dream, a vision of the night,
When sound sleep falls on men,
While they slumber in their beds,
Then He opens the ears of men,
And seals their instruction,
That He may turn man aside from his conduct,
And keep man from pride;
He keeps back his soul from the pit,
And his life from passing over into Sheol.
“Man is also chastened with pain on his bed,
And with unceasing complaint in his bones;
So that his life loathes bread,
And his soul favorite food.
“His flesh wastes away from sight,
And his bones which were not seen stick out.
“Then his soul draws near to the pit,
And his life to those who bring death.
“If there is an angel as mediator for him,
One out of a thousand,
To remind a man what is right for him,
Then let him be gracious to him, and say,
‘Deliver him from going down to the pit,
I have found a ransom’;
Let his flesh become fresher than in youth,
Let him return to the days of his youthful vigor;
Then he will pray to God, and He will accept him,
That he may see His face with joy,
And He may restore His righteousness to man.
“He will sing to men and say,
‘I have sinned and perverted what is right,
And it is not proper for me.
‘He has redeemed my soul from going to the pit,
And my life shall see the light.’
“Behold, God does all these oftentimes with men,
To bring back his soul from the pit," Job 33:14-30.

Nothing happens to us without reason. God loves us and allows circumstances to come our way to get our attention. We are so busy with our own affairs that we fail to see the hand of God in everything.

If we are pure in heart, we shall observe the hand of God:"Blessed are the pure in heart, for they shall see God." Matthew 5:8.